Synergistic effects of chronic bryostatin-1 and alpha-tocopherol on spatial learning and memory in rats.

@article{Sun2008SynergisticEO,
  title={Synergistic effects of chronic bryostatin-1 and alpha-tocopherol on spatial learning and memory in rats.},
  author={Miao-Kun Sun and Daniel L. Alkon},
  journal={European journal of pharmacology},
  year={2008},
  volume={584 2-3},
  pages={
          328-37
        }
}
Evidence is emerging that protein kinase C (PKC) plays a crucial role in the neural processing of memory information and that PKC deficits underlie certain types of memory impairment, including Alzheimer's dementia. Chronic activation of PKC isozymes with bryostatin-1 induces synthesis of the proteins that are involved in memory consolidation and, therefore, may represent a pharmacological strategy for antidementic and memory therapies. PKC isozymes are, however, sensitive to oxidants, whose… Expand
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