Synergistic effects of antiprogestins and iNOS or aromatase inhibitors on establishment and maintenance of pregnancy

@article{Shi2003SynergisticEO,
  title={Synergistic effects of antiprogestins and iNOS or aromatase inhibitors on establishment and maintenance of pregnancy},
  author={L. Shi and S. Shi and R. Given and H. Hertzen and R. Garfield},
  journal={Steroids},
  year={2003},
  volume={68},
  pages={1077-1084}
}
Progesterone is known to be involved in many steps in female reproduction including control of implantation and uterine-cervical function during pregnancy. Our studies in rats and guinea pigs indicate that progesterone inhibits uterine contractility and cervical softening during pregnancy. Progesterone levels or actions decline near the end of pregnancy leading to the onset of labor. Treatment with progestin agonists prolongs pregnancy and inhibits cervical softening, whereas treatment with… Expand

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