Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model.

@article{Krakora2013SynergisticEO,
  title={Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model.},
  author={Dan Krakora and Patrick Mulcrone and Michael M. Meyer and Christina Lewis and Ksenija Bernau and Genevieve Gowing and Chad A. Zimprich and P. Aebischer and Clive Niels Svendsen and Masatoshi Suzuki},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2013},
  volume={21 8},
  pages={1602-10}
}
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons in the brain and spinal cord. We have recently shown that human mesenchymal stem cells (hMSCs) modified to release glial cell line-derived neurotrophic factor (GDNF) decrease disease progression in a rat model of ALS when delivered to skeletal muscle. In the current study, we determined whether or not this effect could be enhanced by delivering GDNF in concert with… CONTINUE READING
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