Synergistic effects of C-peptide and insulin on low O2-induced ATP release from human erythrocytes.

@article{Richards2013SynergisticEO,
  title={Synergistic effects of C-peptide and insulin on low O2-induced ATP release from human erythrocytes.},
  author={Jennifer P Richards and Alan H. Stephenson and Mary L. Ellsworth and Randy S Sprague},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2013},
  volume={305 11},
  pages={R1331-6}
}
Erythrocytes participate in the matching of oxygen (O2) delivery with local need in skeletal muscle via the release of O2 and the vasodilator, ATP. It was reported that a concentration of insulin found in humans with insulin resistance inhibits low O2-induced ATP release. However, in vivo, insulin is coreleased with connecting peptide (C-peptide) at equimolar concentrations, but because of the shorter insulin half-life, the peptides circulate at ratios of C-peptide to insulin ranging from 1:1… CONTINUE READING

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