Synergistic effects in apoptosis induction by taurolidine and TRAIL in HCT-15 colon carcinoma cells.

@article{Chromik2007SynergisticEI,
  title={Synergistic effects in apoptosis induction by taurolidine and TRAIL in HCT-15 colon carcinoma cells.},
  author={Ansgar Michael Chromik and Adrien Daigeler and Christoph Hilgert and Daniel Bulut and Anne Geisler and Veronica G. Liu and Jan M Otte and Waldemar Uhl and Ulrich Mittelk{\"o}tter},
  journal={Journal of investigative surgery : the official journal of the Academy of Surgical Research},
  year={2007},
  volume={20 6},
  pages={339-48}
}
Induction of apoptosis in tumor cells by TRAIL (tumor necrosis factor [TNF]-related apoptosis-inducing ligand) is a promising therapeutic principle in oncology, although toxicity and resistance against TRAIL are limiting factors. Taurolidine (TRD), an antineoplastic agent with low toxicity, is a potential candidate for combined therapy with TRAIL. The aim of this study was to evaluate the apoptotic effects of a combined treatment with TRD and TRAIL in a human HCT-15 colon carcinoma cell line… CONTINUE READING