Synergistic effects between codeine and diclofenac after local, spinal and systemic administration

@article{JimnezAndrade2003SynergisticEB,
  title={Synergistic effects between codeine and diclofenac after local, spinal and systemic administration},
  author={Juan Miguel Jim{\'e}nez-Andrade and Mario I Ortiz and Jos{\'e} Trinidad P{\'e}rez-Urizar and Patricia Aguirre-Ba{\~n}uelos and Vinicio Granados-Soto and Gilberto Casta{\~n}eda-Hern{\'a}ndez},
  journal={Pharmacology Biochemistry and Behavior},
  year={2003},
  volume={76},
  pages={463-471}
}
This study was designed to evaluate the extent of the antinociceptive interaction between codeine and diclofenac at the local, spinal and systemic level. The effects of individual and fixed-ratio combinations of locally, spinally or orally given codeine and diclofenac were assayed using the formalin test in rats. Isobolographic analysis was employed to characterize the synergism produced by the combinations. Codeine, diclofenac and fixed-ratio codeine-diclofenac combinations produced a dose… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Similar Papers

Loading similar papers…