Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats

@article{Rog2002SynergisticEO,
  title={Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats},
  author={Zofia Rog{\'o}ż and Grażyna Skuza and Jerzy G. Maj and Wojciech Danysz},
  journal={Neuropharmacology},
  year={2002},
  volume={42},
  pages={1024-1030}
}
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TLDR
Competitive analysis allowed us to observe an increase in the affinity of &agr;1-adrenergic receptors (Ki) for an agonist (phenylephrine) upon repeated treatment with IMI, given alone or in combination with AMA.
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Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice
TLDR
The results showed that traxoprodil at a dose of 20 and 40 mg/kg exhibited antidepressant activity in the FST and it was not related to changes in animals’ locomotor activity.
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