Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats

  title={Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats},
  author={Zofia Rog{\'o}ż and Grażyna Skuza and Jerzy G. Maj and Wojciech Danysz},
Effect of combined treatment with imipramine and amantadine on the central dopamine D2 and D3 receptors in rats.
Repeated administration of AMA, given together with IMI, induces the up-regulation of dopamine D2 and D3 receptors in the rat brain, and this effect may explain their synergistic action observed in the behavioral studies involving dopaminergic transmission.
Combination therapy of imipramine and melatonin: additive antidepressant effect in mouse forced swimming test.
Involvement of NMDA receptors in the antidepressant-like action of adenosine.
Effects of amantadine and budipine on antidepressant drug‐evoked changes in extracellular 5‐HT in the frontal cortex of freely moving rats
Combined treatment with clinically tolerated NMDA antagonists such as amantadine could reduce the delay in therapeutic onset of antidepressants as well as possibly enhance their efficacy.
NMDA receptor/nitrergic system blockage augments antidepressant-like effects of paroxetine in the mouse forced swimming test
It is suggested, for the first time, a possible role for NMDAR/NO signaling in the antidepressant-like effects of paroxetine, providing a new approach for the treatment of depression.
The effect of combined treatment with imipramine and amantadine on the behavioral reactivity of central &agr;1-adrenergic system in rats
Competitive analysis allowed us to observe an increase in the affinity of &agr;1-adrenergic receptors (Ki) for an agonist (phenylephrine) upon repeated treatment with IMI, given alone or in combination with AMA.
Agmatine enhances the antidepressant-like effect of lithium in mouse forced swimming test through NMDA pathway.
Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice
The results showed that traxoprodil at a dose of 20 and 40 mg/kg exhibited antidepressant activity in the FST and it was not related to changes in animals’ locomotor activity.


A potential antidepressant activity of SA4503, a selective sigma 1 receptor agonist.
The suggestion that SA4503 may have potential antidepressive properties is supported, as it shows a synergistic effect with imipramine and decreased the immobility time in the forced swimming test in rats.
The effect of CGP 37849 and CGP 39551, competitive NMDA receptor antagonists, in the forced swimming test.
The results obtained indicate that CGP 37849 and CGP 39551 induce an antidepressant-like effect in the forced swimming test, probably via an indirect dopamine activation resulting from blockade of NMDA receptors.
5-HT3 receptor antagonists reverse helpless behaviour in rats.
Potential antidepressive properties of amantadine, memantine and bifemelane.
It is suggested that amantadine and bifemelane could be particularly useful therapeutically when depressive symptoms are present in patients suffering from Parkinson's disease and dementia.
Role of the serotonergic system in the forced swimming test
  • F. Borsini
  • Biology, Psychology
    Neuroscience & Biobehavioral Reviews
  • 1995