Synergistic effect of triptolide and tacrolimus on rat cardiac allotransplantation.

  title={Synergistic effect of triptolide and tacrolimus on rat cardiac allotransplantation.},
  author={Ruzheng Li and Kenji Takazawa and Hiromasa Suzuki and Akifusa Hariya and Taira Yamamoto and Satoshi Matsushita and Hitoshi Hirose and Atsushi Amano},
  journal={Japanese heart journal},
  volume={45 4},
Recent studies have shown that triptolide inhibits T cell activation through mechanisms different from those of cyclosporine A and tacrolimus and we postulated that triptolide might have a synergistic effect with tacrolimus to enhance immunosuppression. Using a F344 donor-to-Lewis recipient rat combination, we investigated the immunosuppressive effects of triptolide alone or in combination with tacrolimus on the survival of cardiac allografts. Recipients were treated with placebo, triptolide… CONTINUE READING
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Tacrolimus: an update of its pharmacology and clinical efficacy in the management of organ transplantation

  • CM Spencer, KL Goa, JC. Gillis
  • Drugs
  • 1997

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