Synergistic effect of sorafenib and vitamin K on suppression of hepatocellular carcinoma cell migration and metastasis.

@article{Ha2015SynergisticEO,
  title={Synergistic effect of sorafenib and vitamin K on suppression of hepatocellular carcinoma cell migration and metastasis.},
  author={T Y Ha and Shin Won Hwang and Hea-Nam Hong and Young-Il Choi and Sam-Youl Yoon and You-Jin Won and Gi-Won Song and Nayoung K. D. Kim and Eunyoung Tak and B Ryoo},
  journal={Anticancer research},
  year={2015},
  volume={35 4},
  pages={1985-95}
}
Vitamin K plays a role in controlling cell growth. Anti-angiogenic effects of sorafenib lead to impairment of vitamin K uptake and induction of des-γ-carboxyprothrombin release by hepatocellular carcinoma (HCC) cells. We examined sorafenib and vitamin K individually and in combination regarding their ability to suppress migration and metastatic potential of… CONTINUE READING