Synergistic effect of perfluorochemicals on BCNU chemotherapy. Experimental study in a 9L rat brain-tumor model.

@article{Kuwamura1982SynergisticEO,
  title={Synergistic effect of perfluorochemicals on BCNU chemotherapy. Experimental study in a 9L rat brain-tumor model.},
  author={Keiichi Kuwamura and Takashi Kokunai and Norihiko Tamaki and Satoshi Matsumoto},
  journal={Journal of neurosurgery},
  year={1982},
  volume={57 4},
  pages={
          467-71
        }
}
In a study of the effect of adding perfluorochemicals to BCNU chemotherapy, 7 X 10(5) 9L tumor cells were implanted in the right cerebral hemisphere of Fischer 344 rats weighting about 100 gm each. On the 7th day after implantation, rats were given BCNU or Fluosol-43 (perfluorochemical artificial blood substitute), or a combination of the two, and the therapeutic effects of these treatments were studied. Mean survival time of control animals was 15.23 days +/- 2.84 days (standard deviation); in… CONTINUE READING