Synergistic effect of methanol extract of Abies webbiana leaves on sleeping time induced by standard sedatives in mice and anti-inflammatory activity of extracts in rats.

@article{Nayak2004SynergisticEO,
  title={Synergistic effect of methanol extract of Abies webbiana leaves on sleeping time induced by standard sedatives in mice and anti-inflammatory activity of extracts in rats.},
  author={Siva Sankar Nayak and Ashoke Kumar Ghosh and Bikash Debnath and Satya Prakash Vishnoi and Tarun Jha},
  journal={Journal of ethnopharmacology},
  year={2004},
  volume={93 2-3},
  pages={397-402}
}
During the determination of LD50 values of extracts of Abies webbiana, it was observed that the methanol extract (MEAW) produces sedation of animals. This led to investigation of the effect of MEAW on sleeping time in mice. When various doses of the methanol extract (100, 150, and 200 mg/kg body weight) were administered alone, no hypnotic activity was observed. However, these exhibited significant synergistic effects (P < 0.001) at those dose levels in mice when administered prior to the… CONTINUE READING