Synergistic effect of iontophoresis and soluble microneedles for transdermal delivery of methotrexate.

@article{Vemulapalli2008SynergisticEO,
  title={Synergistic effect of iontophoresis and soluble microneedles for transdermal delivery of methotrexate.},
  author={Viswatej Vemulapalli and Ye Seok Yang and Phillip M. Friden and Ajay K. Banga},
  journal={The Journal of pharmacy and pharmacology},
  year={2008},
  volume={60 1},
  pages={27-33}
}
The aim of this study was to investigate the transdermal iontophoretic delivery of methotrexate, alone or in combination with microneedles, in-vitro and in-vivo using intracutaneous microdialysis in the hairless rat. The average depth of the microdialysis probe in the skin was found to be 0.54 mm. Methotrexate was stable in the presence of an applied electric field as determined by cyclic voltammetry. A current density of 0.4 mA cm(-2) applied for 60 min was used in combination with maltose… CONTINUE READING

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