Synergistic effect of antimicrobial peptide arenicin-1 in combination with antibiotics against pathogenic bacteria.

@article{Choi2012SynergisticEO,
  title={Synergistic effect of antimicrobial peptide arenicin-1 in combination with antibiotics against pathogenic bacteria.},
  author={Hyemin Choi and Dong Gun Lee},
  journal={Research in microbiology},
  year={2012},
  volume={163 6-7},
  pages={479-86}
}
Arenicin-1, a 21-mer antimicrobial peptide, has been known to exert broad bactericidal activity. In this study, the combination effect of arenicin-1 with conventional antibiotics was investigated and all combinations showed synergistic effects against bacterial strains (fractional inhibitory concentration index ≤ 0.75). In an assay using fluorescent dye 3'-(p-hydroxyphenyl) fluorescein (HPF) and hydroxyl radical scavenger thiourea, we demonstrated that combined treatments of arenicin-1 and… CONTINUE READING
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