Synergistic effect of A23187 and a phorbol ester on amylase secretion from rabbit pancreatic acini.

Abstract

The combination of the ionophore A23187 and the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulates amylase secretion from rabbit pancreatic acini up to a level equal to, or slightly higher than when carbachol is used as stimulant. Each of the two compounds alone gives only a minor stimulation. This synergistic effect of A23187 and TPA supports a role of protein kinase C in pancreatic enzyme secretion.

Cite this paper

@article{Pont1984SynergisticEO, title={Synergistic effect of A23187 and a phorbol ester on amylase secretion from rabbit pancreatic acini.}, author={Jan Joep H. H. M. De Pont and A M Fleuren-Jakobs}, journal={FEBS letters}, year={1984}, volume={170 1}, pages={64-8} }