Synergistic effect of κ-carrageenan on oxazolone-induced inflammation in BALB/c mice

  title={Synergistic effect of $\kappa$-carrageenan on oxazolone-induced inflammation in BALB/c mice},
  author={Wei Wu and Feng Wang and Xin Gao and Tingting Niu and Xiaojuan Zhu and Xiaojun Yan and Haimin Chen},
  journal={BMC Gastroenterology},
BackgroundCarrageenan is a traditional ingredient that has been widely used in the food industry. In the present study, we propose a hypothesis that carrageenan is a conditional inflammatory agent. When the intestinal tract is in an “unhealthy” state such as that during bacterial infection or acute inflammation, carrageenan can synergistically enhance the inflammatory response.MethodsBALB/C mice received κ-carrageenan via intragastric administration prior to the induction of oxazolone colitis… 

Dietary κ-carrageenan facilitates gut microbiota-mediated intestinal inflammation.

The results suggest that κ-CGN may not be directly inflammatory, but it creates an environment that favors inflammation by perturbation of gut microbiota composition and then facilitates expansion of pathogens, and this effect may be partially reversed by the introduction of probiotics.

κ-Carrageenan Enhances Lipopolysaccharide-Induced Interleukin-8 Secretion by Stimulating the Bcl10-NF-κB Pathway in HT-29 Cells and Aggravates C. freundii-Induced Inflammation in Mice

Background. The dietary usage of carrageenan as common food additive has increased observably over the last 50 years. But there is substantial controversy about its safety. Methods. We investigated

Dexamethasone downregulates SIRT1 and IL6 and upregulates EDN1 genes in stem cells derived from gingivae via the AGE/RAGE pathway

Application of dexamethasone reduced the expression of SIRT1 and IL6 but enhanced the expression in stem cells but expression of EDN1 of stem cells was increased.

Integral Utilization of Red Seaweed for Bioactive Production

A review of the available conventional and alternative greener and efficient extraction for obtaining red seaweed bioactives is presented, the potential of emerging technologies for the production of valuable oligomers from carrageenan and agar is commented, and the sequential extraction of the constituent fractions is discussed.



Carrageenan-Induced Colonic Inflammation Is Reduced in Bcl10 Null Mice and Increased in IL-10-Deficient Mice

Findings demonstrate a Bcl10 requirement for maximum development of carrageenan-induced inflammation and lack of complete suppression by IL-10 of car rageenan -induced inflammation.

Pulverized konjac glucomannan ameliorates oxazolone-induced colitis in mice

PKGM ameliorated OXA-induced colitis in mice and is associated with a decreased population of NK1.1+ T cells and induction of Th1-polarized immune responses.

Carrageenan induces interleukin-8 production through distinct Bcl10 pathway in normal human colonic epithelial cells.

Exposure of human intestinal epithelial cells to carrageenan triggers a distinct inflammatory pathway via activation of Bcl10 with NF-kappaB activation and upregulation of IL-8 secretion, which may represent a link between genetic and environmental etiologies of inflammatory bowel disease.

Degraded Carrageenan Causing Colitis in Rats Induces TNF Secretion and ICAM-1 Upregulation in Monocytes through NF-κB Activation

Data suggest that the degraded forms of CGN have a pronounced effect on monocytes, characteristic of an inflammatory phenotype, which is linked to NF-κB activation.

Oxazolone Colitis: A Murine Model of  T Helper Cell Type 2 Colitis Treatable with Antibodies to Interleukin 4

The histologic features and distribution of oxazolone colitis have characteristics that resemble ulcerative colitis (UC) and thus sharply distinguish this model from most other models, which usually resemble Crohn's disease.

Short-term peroral toxicity of undegraded carrageenan in pigs.

  • E. Poulsen
  • Chemistry, Medicine
    Food and cosmetics toxicology
  • 1973

Carrageenan induces cell cycle arrest in human intestinal epithelial cells in vitro.

The first studies to determine the effects of CGN exposure on human intestinal epithelial cells (IEC) in tissue culture and the effect of very low concentrations (1-10 mg/L) of undegraded, high-molecular weight CGN are performed, suggesting that C GN exposure may have a role in development of human intestinal pathology.

Common Food Additive Carrageenan Stimulates Wnt/ β-Catenin Signaling in Colonic Epithelium by Inhibition of Nucleoredoxin Reduction

How a common dietary ingredient can contribute to colon carcinogenesis by effects on Wnt signaling and Wnt expression is suggested.

Harmful effects of carrageenan fed to animals.

Its harmful effects in animals are almost certainly associated with its degradation during passage through the gastrointestinal tract, and there is a need for extreme caution in the use of carrageenan or carragean-like products as food additives in the authors' diet, and particularly in slimming recipes.