Synergistic effect of κ-carrageenan on oxazolone-induced inflammation in BALB/c mice

@article{Wu2016SynergisticEO,
  title={Synergistic effect of $\kappa$-carrageenan on oxazolone-induced inflammation in BALB/c mice},
  author={Wei Wu and Feng Wang and Xin Gao and Tingting Niu and Xiaojuan Zhu and Xiaojun Yan and Haimin Chen},
  journal={BMC Gastroenterology},
  year={2016},
  volume={16}
}
BackgroundCarrageenan is a traditional ingredient that has been widely used in the food industry. In the present study, we propose a hypothesis that carrageenan is a conditional inflammatory agent. When the intestinal tract is in an “unhealthy” state such as that during bacterial infection or acute inflammation, carrageenan can synergistically enhance the inflammatory response.MethodsBALB/C mice received κ-carrageenan via intragastric administration prior to the induction of oxazolone colitis… 

Dietary κ-carrageenan facilitates gut microbiota-mediated intestinal inflammation.

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κ-Carrageenan Enhances Lipopolysaccharide-Induced Interleukin-8 Secretion by Stimulating the Bcl10-NF-κB Pathway in HT-29 Cells and Aggravates C. freundii-Induced Inflammation in Mice

Background. The dietary usage of carrageenan as common food additive has increased observably over the last 50 years. But there is substantial controversy about its safety. Methods. We investigated

Dexamethasone downregulates SIRT1 and IL6 and upregulates EDN1 genes in stem cells derived from gingivae via the AGE/RAGE pathway

Application of dexamethasone reduced the expression of SIRT1 and IL6 but enhanced the expression in stem cells but expression of EDN1 of stem cells was increased.

Integral Utilization of Red Seaweed for Bioactive Production

A review of the available conventional and alternative greener and efficient extraction for obtaining red seaweed bioactives is presented, the potential of emerging technologies for the production of valuable oligomers from carrageenan and agar is commented, and the sequential extraction of the constituent fractions is discussed.

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