Synergistic dual positive feedback loops established by molecular sequestration generate robust bimodal response.

@article{Venturelli2012SynergisticDP,
  title={Synergistic dual positive feedback loops established by molecular sequestration generate robust bimodal response.},
  author={Ophelia S Venturelli and Hana El-Samad and Richard M. Murray},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 48},
  pages={
          E3324-33
        }
}
Feedback loops are ubiquitous features of biological networks and can produce significant phenotypic heterogeneity, including a bimodal distribution of gene expression across an isogenic cell population. In this work, a combination of experiments and computational modeling was used to explore the roles of multiple feedback loops in the bimodal, switch-like response of the Saccharomyces cerevisiae galactose regulatory network. Here, we show that bistability underlies the observed bimodality, as… CONTINUE READING

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