Synergistic dual-ligand doxorubicin liposomes improve targeting and therapeutic efficacy of brain glioma in animals.

@article{Zong2014SynergisticDD,
  title={Synergistic dual-ligand doxorubicin liposomes improve targeting and therapeutic efficacy of brain glioma in animals.},
  author={Taili Zong and Ling Mei and Huile Gao and Wei Cai and Pengjin Zhu and Kairong Shi and Jiantao Chen and Yang Wang and Fabao Gao and Qin He},
  journal={Molecular pharmaceutics},
  year={2014},
  volume={11 7},
  pages={2346-57}
}
Therapeutic outcome for the treatment of glioma was often limited due to low permeability of delivery systems across the blood-brain barrier (BBB) and poor penetration into the tumor tissue. In order to overcome these hurdles, we developed the dual-targeting doxorubicin liposomes conjugated with cell-penetrating peptide (TAT) and transferrin (T7) (DOX-T7-TAT-LIP) for transporting drugs across the BBB, then targeting brain glioma, and penetrating into the tumor. The dual-targeting effects were… CONTINUE READING
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