Synergistic cytotoxicity between menadione and dicumarol vs. murine leukemia L1210.

@article{Akman1987SynergisticCB,
  title={Synergistic cytotoxicity between menadione and dicumarol vs. murine leukemia L1210.},
  author={Steven A. Akman and James H. Doroshow and Marian Dietrich and Rowan Chlebowski and Jake Block},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1987},
  volume={240 2},
  pages={486-91}
}
The water-soluble derivative of vitamin K, menadiol sodium bisulfite (K3), and the related anticoagulant dicumarol, inhibited growth of murine leukemia L1210 in liquid suspension culture. K3, but not dicumarol, cytotoxicity was abrogated by 1 mM cysteine. Isobolographic analysis of the effect of K3-dicumarol combinations, in the concentration ranges between 5 and 75 microM, on L1210 growth, indicated synergy between the two drugs. K3 (10 microM) caused a 3-fold stimulation of KCN-resistant O2… CONTINUE READING

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The water - soluble derivative of vitamin K , menadiol sodium bisulfite ( K3 ) , and the related anticoagulant dicumarol , inhibited growth of murine leukemia L1210 in liquid suspension culture .
The water - soluble derivative of vitamin K , menadiol sodium bisulfite ( K3 ) , and the related anticoagulant dicumarol , inhibited growth of murine leukemia L1210 in liquid suspension culture .
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