Synergistic cytotoxic effect of azidothymidine and recombinant interferon alpha on normal human bone marrow progenitor cells.

@article{Berman1989SynergisticCE,
  title={Synergistic cytotoxic effect of azidothymidine and recombinant interferon alpha on normal human bone marrow progenitor cells.},
  author={Ellin Berman and R Duigou-Osterndorf and Susan E. Krown and Michael P. Fanucchi and Jason Chou and Martin S. Hirsch and Bayard D. Clarkson and Ting Chao Chou},
  journal={Blood},
  year={1989},
  volume={74 4},
  pages={1281-6}
}
Azidothymidine (AZT) and interferon alpha (IFN-alpha) are among the drugs showing strong in vitro activity against the human immunodeficiency virus type-1 (HIV-1). Each drug, however, has significant toxicity against normal marrow progenitor cells that frequently proves dose-limiting in patients. In this study, AZT and recombinant IFN-alpha 2a (rIFN-alpha 2a) were tested as single agents and in combination against normal myeloid (CFU-GM) and erythroid (BFU-E) colony forming cells in a standard… CONTINUE READING

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