Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression.

@article{SnchezElsner2001SynergisticCB,
  title={Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression.},
  author={Tilman S{\'a}nchez-Elsner and Luisa M Botella and Beatriz Soubriet Velasco and A Corb{\'i} and Liliana Attisano and Carmelo Bernabeu},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 42},
  pages={38527-35}
}
Signaling by transforming growth factor (TGF)-beta family members is mediated by Smad proteins that regulate gene transcription through functional cooperativity and association with other DNA-binding proteins. The hypoxia-inducible factor (HIF)-1 is a transcriptional complex that plays a key role in oxygen-regulated gene expression. We demonstrate that… CONTINUE READING