Synergistic control of mesenchymal stem cell differentiation by nanoscale surface geometry and immobilized growth factors on TiO2 nanotubes.

@article{Park2012SynergisticCO,
  title={Synergistic control of mesenchymal stem cell differentiation by nanoscale surface geometry and immobilized growth factors on TiO2 nanotubes.},
  author={Jung Ju Park and Sebastian Bauer and Andreas Pittrof and Manuela S Killian and Patrik Schmuki and Klaus von der Mark},
  journal={Small},
  year={2012},
  volume={8 1},
  pages={98-107}
}
The aim of this study is to elucidate whether combined environmental signals provided by nanoscale topography and by growth factors control cell behavior of mesenchymal stem cells (MSCs) in a synergistic or simply additive manner. Chondrogenic and osteogenic differentiation of MSCs is studied on vertically aligned TiO(2) nanotubes of size 15 and 100 nm with and without immobilized bone morphogenetic protein-2 (BMP-2). Although BMP-2 coating stimulates both chondrogenic and osteogenic… CONTINUE READING
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