Synergistic chemoprotective mechanisms of dietary phytoestrogens in a select combination against prostate cancer.

@article{Kumar2011SynergisticCM,
  title={Synergistic chemoprotective mechanisms of dietary phytoestrogens in a select combination against prostate cancer.},
  author={Rajeev Kumar and Vikas Verma and Ashish Jain and Rajeev Kumar Jain and Jagdamba Prasad Maikhuri and Gopal N. Gupta},
  journal={The Journal of nutritional biochemistry},
  year={2011},
  volume={22 8},
  pages={723-31}
}
Combination of dietary phytoestrogens with diverse molecular mechanisms may enhance their anticancer efficacy at physiological concentrations, as evidenced in epidemiological studies. A select combination of three dietary phytoestrogens containing 8.33 μM each of genistein (G), quercetin (Q) and biochanin A (B) was found to be more potent in inhibiting the growth of androgen-responsive prostate cancer cells (LNCaP) as well as DU-145 and PC-3 prostate cancer cells in vitro than either 25 μM of G… CONTINUE READING
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