Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.

@article{Takeuchi2005SynergisticAO,
  title={Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.},
  author={Hayato Takeuchi and Yasuko Kondo and Keishi Fujiwara and Takao Kanzawa and Hiroshi Aoki and Gordon B Mills and Seiji Kondo},
  journal={Cancer research},
  year={2005},
  volume={65 8},
  pages={
          3336-46
        }
}
The mammalian target of rapamycin (mTOR) is a downstream effector of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway and a central modulator of cell proliferation in malignant gliomas. Therefore, the targeting of mTOR signaling is considered a promising therapy for malignant gliomas. However, the mechanisms underlying the cytotoxic effects of a selective mTOR inhibitor, rapamycin, on malignant glioma cells are poorly understood. The purpose of this study was… CONTINUE READING

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