Synergistic attenuation of vesicular stomatitis virus by combination of specific G gene truncations and N gene translocations.

@article{Clarke2007SynergisticAO,
  title={Synergistic attenuation of vesicular stomatitis virus by combination of specific G gene truncations and N gene translocations.},
  author={David K. Clarke and Farooq Nasar and Margaret T. Lee and John E. Johnson and Kevin J. R. Wright and Priscilla C Calderon and Min Guo and Robert J. Natuk and David Cooper and R. Michael Hendry and Stephen A. Udem},
  journal={Journal of virology},
  year={2007},
  volume={81 4},
  pages={2056-64}
}
A variety of rational approaches to attenuate growth and virulence of vesicular stomatitis virus (VSV) have been described previously. These include gene shuffling, truncation of the cytoplasmic tail of the G protein, and generation of noncytopathic M gene mutants. When separately introduced into recombinant VSV (rVSV), these mutations gave rise to viruses… CONTINUE READING