Synergistic apoptotic effect of crocin and cisplatin on osteosarcoma cells via caspase induced apoptosis.

@article{Li2013SynergisticAE,
  title={Synergistic apoptotic effect of crocin and cisplatin on osteosarcoma cells via caspase induced apoptosis.},
  author={Xiucheng Li and Tao Huang and Guangjian Jiang and Weihua Gong and Heng Qian and Chunping Zou},
  journal={Toxicology letters},
  year={2013},
  volume={221 3},
  pages={197-204}
}
Crocin is well-known traditional Chinese medicine which is extracted from saffron. However, its role in osteosarcoma has not been well understood. Therefore, we used crocin and cisplatin individually or jointly on MG63 and OS732 cells so as to explore whether crocin could induce cellular apoptosis and suppress the ability of invasion of osteosarcoma cells. Cell survival rates, changes of cellular shape, cell apoptosis and cell invasion were analyzed, respectively, by 3-(4,5)-dimethylthiahiazo… CONTINUE READING