Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignant mesothelioma.

Abstract

CD4(+)CD25(+) regulatory T cells (Tregs) can promote the growth of some tumors, but it is unknown whether this is true for all tumors, including malignant pleural mesothelioma. We have previously shown that the existence of Tregs was associated with poor survival in patients with malignant pleural mesothelioma. In this study, using an intrathoracic murine… (More)
DOI: 10.4049/jimmunol.0900437

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@article{Anraku2010SynergisticAE, title={Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignant mesothelioma.}, author={Masaki Anraku and Tetsuzo Tagawa and Licun Wu and Zhihong Yun and Shaf H Keshavjee and Li Zhang and Michael R. Johnston and Marc E de Perrot}, journal={Journal of immunology}, year={2010}, volume={185 2}, pages={956-66} }