Synergistic antitumor activity of interleukin-2 and cimetidine against syngeneic murine tumor


Cimetidine, an H2 histamine receptor antagonist, is a potent immunomodulating agent, which acts by inhibiting suppressor T lymphocyte function. The present work investigated the effect, if any, of cimetidine on interleukin-2 (IL-2)-induced natural killer (NK) and lymphokine-activated killer (LAK) cell activities, and on in vivo antitumor activity using… (More)
DOI: 10.1007/BF01742521

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