Synergistic antiproliferative effect of imatinib and adriamycin in platelet-derived growth factor receptor-expressing osteosarcoma cells

@inproceedings{Yamaguchi2015SynergisticAE,
  title={Synergistic antiproliferative effect of imatinib and adriamycin in platelet-derived growth factor receptor-expressing osteosarcoma cells},
  author={Sayaka I. Yamaguchi and Arisa Ueki and Eiji Sugihara and Nobuyuki Onishi and Tomonori Yaguchi and Yutaka Kawakami and Keisuke Horiuchi and Hideo Morioka and Morio Matsumoto and Masaya Nakamura and Akihiro Muto and Yoshiaki Toyama and Hideyuki Saya and Takatsune Shimizu},
  booktitle={Cancer science},
  year={2015}
}
Osteosarcoma (OS) is the most frequent primary solid malignant tumor of bone. Its prognosis remains poor in the substantial proportion of patients who do not respond to chemotherapy and novel therapeutic options are therefore needed. We previously established a mouse model that mimics the aggressive behavior of human OS. Enzyme-linked immunosorbent assay-based screening of such mouse tumor lysates identified platelet-derived growth factor-BB (PDGF-BB) as an abundant soluble factor, the gene for… CONTINUE READING