Synergistic antinociceptive interaction after epidural coadministration of morphine and lidocaine in rats.

@article{Kaneko1994SynergisticAI,
  title={Synergistic antinociceptive interaction after epidural coadministration of morphine and lidocaine in rats.},
  author={Michio Kaneko and Yoji Saito and Yumiko Kirihara and Jerry G. Collins and Yasuharu Kosaka},
  journal={Anesthesiology},
  year={1994},
  volume={80 1},
  pages={137-50}
}
BACKGROUND Clinically, epidural coadministration of opioids and local anesthetics has provided excellent analgesia for various types of pain. However, information about the interaction of these drugs when administered epidurally is limited. Therefore, we evaluated the antinociceptive interaction between morphine and lidocaine on both somatic and visceral noxious stimuli in the rat. METHODS Male Sprague-Dawley rats weighing 300-350 g had epidural catheters implanted at T13-L1. Every rat was… CONTINUE READING

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