Synergistic antinociceptive effects of ketamine and morphine in the orofacial capsaicin test in the rat.

@article{Alvarez2003SynergisticAE,
  title={Synergistic antinociceptive effects of ketamine and morphine in the orofacial capsaicin test in the rat.},
  author={Pedro I Alvarez and Gloria Saavedra and Alejandro Hern{\'a}ndez and Carlos Paeile and Teresa P{\'e}lissier},
  journal={Anesthesiology},
  year={2003},
  volume={99 4},
  pages={969-75}
}
BACKGROUND The clinical efficacy of the noncompetitive N-methyl-d-aspartate receptor antagonist ketamine for treating orofacial pain has already been reported. Side effects related to psychotomimetic disturbances, however, limit ketamine use as an analgesic. Theoretically, this limitation could be minimized by using low doses of ketamine in combination with other analgesics. In the present study, the potential synergistic antinociceptive interaction between ketamine and morphine in the… CONTINUE READING
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