Synergistic antinociceptive effect of amitriptyline and morphine in the rat orofacial formalin test.

@article{Luccarini2004SynergisticAE,
  title={Synergistic antinociceptive effect of amitriptyline and morphine in the rat orofacial formalin test.},
  author={Philippe Luccarini and Laurent Perrier and C{\'e}line D{\'e}goulange and Anne-Marie Gaydier and Radhouane Dallel},
  journal={Anesthesiology},
  year={2004},
  volume={100 3},
  pages={690-6}
}
BACKGROUND Combination therapy is often used to increase the clinical utility of analgesic agents. The coadministration of two compounds may achieve analgesia at doses lower than those required for either compound alone, leading to enhanced pain relief and reduction of adverse effects. Herein, the authors describe the effect of coadministration of morphine and amitriptyline on cutaneous orofacial inflammatory pain in rats. METHODS Amitriptyline, morphine, or the combination of amitriptyline… CONTINUE READING

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Tricyclic and other antidepressants as analgesics, Novel Aspects of Pain Management: Opioids and Beyond

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