Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways.

@article{Jia2003SynergisticAI,
  title={Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways.},
  author={Wentao Jia and Chunrong Yu and Mohamed Rahmani and Geoffrey W. Krystal and Edward A. Sausville and Paul Dent and Steven Grant},
  journal={Blood},
  year={2003},
  volume={102 5},
  pages={1824-32}
}
Interactions between the protein kinase C (PKC) and Chk1 inhibitor UCN-01 and the heat shock protein 90 (Hsp90) antagonist 17-AAG have been examined in human leukemia cells in relation to effects on signal transduction pathways and apoptosis. Simultaneous exposure (30 hours) of U937 monocytic leukemia cells to minimally toxic concentrations of 17-AAG (eg, 400 nM) and UCN-01 (eg, 75 nM) triggered a pronounced increase in mitochondrial injury (ie, loss of mitochondrial membrane potential… CONTINUE READING
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Heat shock protein inhibitor shows antitumor activity

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