Synergistic antidepressant-like effects between a kappa opioid antagonist (LY2444296) and a delta opioid agonist (ADL5859) in the mouse forced swim test.

@article{Huang2016SynergisticAE,
  title={Synergistic antidepressant-like effects between a kappa opioid antagonist (LY2444296) and a delta opioid agonist (ADL5859) in the mouse forced swim test.},
  author={Peng Huang and Julia Tunis and Christopher Parry and Ronald J. Tallarida and Lee-Yuan Liu-Chen},
  journal={European journal of pharmacology},
  year={2016},
  volume={781},
  pages={
          53-9
        }
}
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While animal studies have indicated that compounds of this structural class are capable of normalizing withdrawal signs in animal models of cocaine and alcohol dependence and reducing cocaine andalcohol intake/seeking, additional studies are needed to determine the value of these second generation KOR antagonists in treating mood disorders and substance use disorders in humans.
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Preclinical and clinical evidence supporting the antidepressant-like effects of opioid ligands, and in particular, delta opioid receptor (DOR) agonists, are explored.
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This chapter describes several classes of multifunctional ligands that interact with at least one opioid receptor and the structures, pharmacological utility, and therapeutic drawbacks of these classes of ligands are discussed.
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