Synergistic antidepressant-like effect of the joint administration of caffeine and NMDA receptor ligands in the forced swim test in mice

@inproceedings{Serefko2015SynergisticAE,
  title={Synergistic antidepressant-like effect of the joint administration of caffeine and NMDA receptor ligands in the forced swim test in mice},
  author={Anna Serefko and Aleksandra Szopa and Aleksandra Wlaź and Sylwia Wośko and Piotr Wlaź and Ewa J Poleszak},
  booktitle={Journal of Neural Transmission},
  year={2015}
}
The optimal treatment of depressed patients remains one of the most important challenges concerning depression. The identification of the best treatment strategies and development of new, safer, and more effective agents are crucial. The glutamatergic system seems to be a promising drug target, and consequently the use of the NMDA receptor ligands, particularly in co-administration with other substances exerting the antidepressant activity, has emerged among the new ideas. The objective of this… CONTINUE READING