Synergistic antibody induction by antigen-CD40 ligand fusion protein as improved immunogen.

  • Wei Li
  • Published 2005 in Immunology

Abstract

Full scale B-cell activation requires not only B-cell receptor (BCR) engagement with antigen, but also costimulatory signals provided by T helper cells through the CD40-CD40 ligand (CD40L) interaction. It is hypothesized that a fusion protein of an antigen and soluble CD40L (CD40LT) would selectively target the costimulation to antigen-specific B cells… (More)

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Cite this paper

@article{Li2005SynergisticAI, title={Synergistic antibody induction by antigen-CD40 ligand fusion protein as improved immunogen.}, author={Wei Li}, journal={Immunology}, year={2005}, volume={115 2}, pages={215-22} }