Synergistic and hierarchical adhesive and topographic guidance of BHK cells.

@article{Britland1996SynergisticAH,
  title={Synergistic and hierarchical adhesive and topographic guidance of BHK cells.},
  author={Stephen Britland and Hywel Morgan and B Wojiak-Stodart and Mathis Riehle and Adam Curtis and C D W Wilkinson},
  journal={Experimental cell research},
  year={1996},
  volume={228 2},
  pages={313-25}
}
Guided cell movement is a fundamental process in development and regeneration. We have used microengineered culture substrates to study the interaction between model topographic and adhesive guidance cues in steering BHK cell orientation. Grooves 0.1, 0.5, 1.0, 3.0, and 6.0 microm deep together with pitch-matched aminosilane tracks 5, 12, 25, 50, and 100 microm wide were fabricated on fused silica substrates using photolithographic and dry-etching techniques. The cues were presented to the… CONTINUE READING

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