Synergistic analgesic interactions between the periaqueductal gray and the locus coeruleus

@article{Bodnar1991SynergisticAI,
  title={Synergistic analgesic interactions between the periaqueductal gray and the locus coeruleus},
  author={Richard J Bodnar and Dennis Paul and Gavril W Pasternak},
  journal={Brain Research},
  year={1991},
  volume={558},
  pages={224-230}
}
Opiates modulate pain perception at a number of different levels within the central nervous system and the importance of synergistic spinal and supraspinal influences have been well documented. In the present study we demonstrate synergistic interactions between the periaqueductal gray and locus coeruleus. Administered either systemically or intracerebroventricularly (i.c.v.), ethylketocyclazocine elicits a potent naloxonazine-sensitive analgesia, indicating a mu 1 action. mu 1 Receptors also… CONTINUE READING

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