Synergistic adaptive mutations in the hemagglutinin and polymerase acidic protein lead to increased virulence of pandemic 2009 H1N1 influenza A virus in mice.

@article{Seyer2012SynergisticAM,
  title={Synergistic adaptive mutations in the hemagglutinin and polymerase acidic protein lead to increased virulence of pandemic 2009 H1N1 influenza A virus in mice.},
  author={Roman Seyer and Eike Roman Hrincius and Dorothea Ritzel and Marion Abt and Alexander Mellmann and Henju Marjuki and Joachim M K{\"u}hn and Thorsten Wolff and Stephan Ludwig and Christina Ehrhardt},
  journal={The Journal of infectious diseases},
  year={2012},
  volume={205 2},
  pages={262-71}
}
Influenza impressively reflects the paradigm of a viral disease in which continued evolution of the virus is of paramount importance for annual epidemics and occasional pandemics in humans. Because of the continuous threat of novel influenza outbreaks, it is essential to gather further knowledge about viral pathogenicity determinants. Here, we explored the adaptive potential of the influenza A virus subtype H1N1 variant isolate A/Hamburg/04/09 (HH/04) by sequential passaging in mice lungs… CONTINUE READING