Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models

@inproceedings{Proia2011SynergisticAO,
  title={Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models},
  author={David A. Proia and Jim Sang and Suqin He and Donald L. Smith and Manuel Sequeira and Chaohua Zhang and Yuan Liu and Shuxia Ye and Dan Zhou and Ronald K. Blackman and Kevin P. Foley and Keizo Koya and Yumiko Wada},
  booktitle={Investigational New Drugs},
  year={2011}
}
Systemic chemotherapy using two-drug platinum-based regimens for the treatment of advanced stage non-small cell lung cancer (NSCLC) has largely reached a plateau of effectiveness. Accordingly, efforts to improve survival and quality of life outcomes have more recently focused on the use of molecularly targeted agents, either alone or in combination with standard of care therapies such as taxanes. The molecular chaperone heat shock protein 90 (Hsp90) represents an attractive candidate for… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Similar Papers

Loading similar papers…