Synergistic activation of transcription by CBP and p53

  title={Synergistic activation of transcription by CBP and p53},
  author={Wei Gu and Xiao-lu Shi and Robert G Roeder},
The tumour suppressor p53 is a transcriptional regulator whose ability to inhibit cell growth is dependent upon its transactivation function. Here we demonstrate that the transcription factor CBP, which is also implicated in cell proliferation and differentiation, acts as a p53 coactivator and potentiates its transcriptional activity. The amino-terminal activation domain of p53 interacts with the carboxy-terminal portion of the CBP protein both in vitro and in vivo. In transfected SaoS-2 cells… CONTINUE READING