Synergistic activation of the type I adenylyl cyclase by Ca2+ and Gs-coupled receptors in vivo.

@article{Wayman1994SynergisticAO,
  title={Synergistic activation of the type I adenylyl cyclase by Ca2+ and Gs-coupled receptors in vivo.},
  author={Gary A. Wayman and Soren Impey and Zhongying Wu and W. Kindsvogel and L B Prichard and Daniel R Storm},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 41},
  pages={
          25400-5
        }
}
The type I adenylyl cyclase is directly stimulated by Ca2+ and calmodulin in vivo (Choi, E. J., Wong, S. T., Hinds, T. R. and Storm, D. R. (1992) J. Biol. Chem. 267, 12440-12442; Wu, Z., Wong, S. T., and Storm, D. R. (1993) J. Biol. Chem. 268, 23766-23768). In this study, we examined the sensitivity of the type I adenylyl cyclase expressed in HEK-293 cells to beta-adrenergic agonists or glucagon when intracellular Ca2+ was elevated by Ca2+ ionophore or carbachol. Although previous studies have… CONTINUE READING
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