Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects.

@article{Buhtoiarov2006SynergisticAO,
  title={Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects.},
  author={Ilia N. Buhtoiarov and Hillary D. Lum and Gideon Berke and Paul M. Sondel and Alexander L. Rakhmilevich},
  journal={Journal of immunology},
  year={2006},
  volume={176 1},
  pages={309-18}
}
We have previously shown that macrophages (Mphi) can be activated by CD40 ligation to become cytotoxic against tumor cells in vitro. Here we show that treatment of mice with agonistic anti-CD40 mAb (anti-CD40) induced up-regulation of intracellular TLR9 in Mphi and primed them to respond to CpG-containing oligodeoxynucleotides (CpG), resulting in synergistic activation. The synergy between anti-CD40 and CpG was evidenced by increased production of IFN-gamma, IL-12, TNF-alpha, and NO by Mphi, as… CONTINUE READING

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