Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver.

@article{Gupte2009SynergisticAO,
  title={Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver.},
  author={Rakhee S Gupte and Beverly C Floyd and Mark Kozicky and Shimran George and Zoltan Ungvari and Vanessa Neito and Michael S. Wolin and Sachin A. Gupte},
  journal={Free radical biology & medicine},
  year={2009},
  volume={47 3},
  pages={219-28}
}
Glucose metabolism through the glycolysis and hexosamine pathway has been shown to be altered in type 2 diabetes. However, the fate of glucose through the pentose phosphate pathway (PPP) is currently unclear. In this study, we determined whether the activity of glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the PPP, is modulated in the liver of Zucker obese fa/fa rats (9-11 weeks of age). We found that G6PD expression and activity, NADPH levels, and 6-phosphogluconate… CONTINUE READING

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