Synergistic activation by the glutamine-rich domains of human transcription factor Sp1

@article{Courey1989SynergisticAB,
  title={Synergistic activation by the glutamine-rich domains of human transcription factor Sp1},
  author={A. Courey and D. Holtzman and S. Jackson and R. Tjian},
  journal={Cell},
  year={1989},
  volume={59},
  pages={827-836}
}
We have examined the role of protein-protein interactions in modulating the activity of Sp1, a human transcription factor that utilizes glutamine-rich activation domains. These domains may represent a commonly used structural motif, since a nonhomologous glutamine-rich segment from the Drosophila Antennapedia protein is also a potent activator when fused to the Sp1 DNA binding domain. Sp1 is generally considered a proximal promoter factor that can only stimulate transcription when bound close… Expand
Interaction between isolated transcriptional activation domains of Sp1 revealed by heteronuclear magnetic resonance
Gene regulation by Sp1 and Sp3.
The Sp-family of transcription factors.
Transcriptional regulation by the Sp family proteins.
A tryptophan-rich peptide acts as a transcription activation domain
Regulation of the activity of Sp1-related transcription factors
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