Synergistic action of vasodilators that increase cGMP and cAMP in the hamster cremaster microcirculation.

Abstract

OBJECTIVE Compounds such as endothelium derived nitric oxide (NO) and prostacyclin (prostaglandin I2) which increase cGMP and cAMP inhibit platelet activation in a synergistic manner. The aim of this study was to examine whether these compounds also interact synergistically in the control of smooth muscle tone. METHODS Vascular diameters in the cremaster… (More)

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