Synergistic action of tiazofurin and retinoic acid on differentiation and colony formation of HL-60 leukemia cells.

@article{Yamaji1990SynergisticAO,
  title={Synergistic action of tiazofurin and retinoic acid on differentiation and colony formation of HL-60 leukemia cells.},
  author={Yasufumi Yamaji and Yutaka Natsumeda and Y Yamada and Sh{\^o}zo Irino and George Weber},
  journal={Life sciences},
  year={1990},
  volume={46 6},
  pages={
          435-42
        }
}
Tiazofurin and retinoic acid synergistically induced differentiation and inhibited colony formation in HL-60 human promyelocytic leukemia cells in cell culture. The synergism was the result of different mechanisms of action, since the effect of tiazofurin, unlike that of retinoic acid, was prevented by addition of guanosine. Since it has been shown that tiazofurin down-regulated the expression of c-Ki-ras oncogene, and retinoic acid that of the myc oncogene, the joint impact of these drugs is… Expand
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