Synergistic action of tiazofurin and genistein on growth inhibition and differentiation of K-562 human leukemic cells.

@article{Li1998SynergisticAO,
  title={Synergistic action of tiazofurin and genistein on growth inhibition and differentiation of K-562 human leukemic cells.},
  author={Wenting Li and G{\"u}nther Weber},
  journal={Life sciences},
  year={1998},
  volume={63 22},
  pages={
          1975-81
        }
}
Tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide, NSC 286193), an oncolytic drug, inhibits IMP DH (inosine 5'-monophosphate dehydrogenase, EC 1.1.1.205), reduces signal transduction activity and IP3 (inositol 1,4,5-trisphosphate) concentration and arrests the cell cycle chiefly in S phase. Genistein (4',5,7-trihydroxyisoflavone), an inhibitor of PIP kinase (1-phosphatidylinositol 4-phosphate 5-kinase, EC 2.7.1.68), tyrosine kinase and topoisomerase-II, induces arrest in G2 and/or early… Expand
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