Corpus ID: 614512

Synergistic action of tiazofurin and genistein in human ovarian carcinoma cells.

@article{Li1998SynergisticAO,
  title={Synergistic action of tiazofurin and genistein in human ovarian carcinoma cells.},
  author={Wenting Li and G{\"u}nther Weber},
  journal={Oncology research},
  year={1998},
  volume={10 3},
  pages={
          117-22
        }
}
Tiazofurin, an oncolytic drug, reduces PI kinase activity and arrests chiefly in S phase. Genistein, an inhibitor of PIP kinase, tyrosine kinase, and topoisomerase-II, induces arrest in G2 and/or early M phase in most carcinoma cells. Both tiazofurin and genistein reduce second messenger IP3 concentration in ovarian carcinoma cells. Because genistein and tiazofurin attack different enzymic targets and arrest the cell cycle at different phases, we tested the hypothesis that tiazofurin might be… Expand
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