Synergistic action of protease-modulating matrix and autologous growth factors in healing of diabetic foot ulcers. A prospective randomized trial.

@article{Kakagia2007SynergisticAO,
  title={Synergistic action of protease-modulating matrix and autologous growth factors in healing of diabetic foot ulcers. A prospective randomized trial.},
  author={Despoina D Kakagia and Konstantinos J. Kazakos and Konstantinos C. Xarchas and Michael A Karanikas and George S Georgiadis and Gregory Tripsiannis and Constantinos Manolas},
  journal={Journal of diabetes and its complications},
  year={2007},
  volume={21 6},
  pages={
          387-91
        }
}
This study tests the hypothesis that addition of a protease-modulating matrix enhances the efficacy of autologous growth factors in diabetic ulcers. Fifty-one patients with chronic diabetic foot ulcers were managed as outpatients at the Democritus University Hospital of Alexandroupolis and followed up for 8 weeks. All target ulcers were > or = 2.5 cm in any one dimension and had been previously treated only with moist gauze. Patients were randomly allocated in three groups of 17 patients each… CONTINUE READING
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