Synergistic action by multi-targeting compounds produces a potent compound combination for human NSCLC both in vitro and in vivo

@inproceedings{Zhang2014SynergisticAB,
  title={Synergistic action by multi-targeting compounds produces a potent compound combination for human NSCLC both in vitro and in vivo},
  author={Chenlu Zhang and Sulan Zhai and Xiaoguang Li and Q-y Zhang and Liang Yu Wu and Ying-xi Liu and Chunqian Jiang and Hua Zhou and Fangda Li and Shulan Zhang and Guohai Su and Blomqvist A Zhang and Bing Yan},
  booktitle={Cell Death and Disease},
  year={2014}
}
By screening a collection of one hundred combinations of thiazolidinone compounds, we identified one combination (M4) that synergistically inhibited the growth of H460 and H460/TaxR cells and tumor growth in H460/TaxR xenograft mice. A whole genome microarray assay showed that genes involved in negative regulation of microtubule polymerization or depolymerization, intracellular protein kinase cascade, positive regulation of histone acetylation, cell cycle arrest and apoptosis were upregulated… CONTINUE READING
BETA

References

Publications referenced by this paper.
SHOWING 1-10 OF 55 REFERENCES

Similar Papers

Loading similar papers…